Scientist, Antibody Engineering
SystImmune, a fast-growing antibody therapeutics company located in Redmond, Washington, is seeking a highly-motivated Scientist to support our antibody engineering efforts. The ideal candidate will have experience in and deep understanding of early-stage drug discovery as it pertains to antibodies and antibody-based biotherapeutics, especially multi-specific and ADC platforms. This person must show a meticulous level of detail and be able to generate timely results with a high degree of accuracy and reproducibility. Priorities will revolve around timeline driven assessment of new therapeutic targets, reagent proteins and proof-of-concept molecules. Scientist level depends on experience.
Research, design, construct, express and characterize antibody-based biotherapeutics and reagent proteins.
Perform antibody characterization and biochemical interaction analysis using biolayer interferometry, ELISA and other bioassay formats, FACS, SDS-PAGE and Western blot.
Lead multi-disciplinary research teams in an innovative and collaborative environment.
Validate targets for programs in oncology, autoimmunity, inflammation and immuno-oncology.
Maintain a current understanding of applicable technologies for ADC and bispecific proteins.
PhD with 5+ years or BS/MS degree in relevant field with a minimum of 10+ years of experience in the biotechnology sector.
Strong skills in structure biology and rational design
Current level of understanding in the field of biotherapeutics for oncology, autoimmunity and inflammation.
Extensive experience with PCR methods, cloning and other common molecular biology techniques is required.
ELISA/cELISA and Flow cytometry proficiency required.
Experience with surface plasmon resonance or biolayer interferometry preferred.
Demonstrate strong organizational and sample-tracking skills.
Ability to work collaboratively as part of a team.
Protein modeling not required, but is a plus.
Previous project management experience is a plus.
is a newly-established, fast-growing antibody therapeutics company
located in Redmond, Washington. We are seeking highly motivated immunologists with
direct experiences in the area of immune-oncology. The successful
candidates should have a broad expertise in many aspects of
immunology and oncology including the immune response against cancer
cells, T cell, NK cell, or myeloid suppressor cell biology, antibody
drug development and target validation. The
successful candidates must be highly-organized, detail-oriented, and
be able to multitask in a fast-paced and dynamic startup environment.
The ideal candidates:
Have led projects in biotechnology or pharmaceutical industry setting in the discovery and development of monoclonal or bi-specific antibody therapeutics that activate the immune system to recognize and eliminate cancer cells.
Can demonstrate a deep knowledge and understanding of tumor microenvironment, T cell, dendritic cell, NK cell, and microphage biology/immunology, etc.
Have solid hands-on experiences in cell-based assay development and in vivo animal models study design for immune-oncology targets.
Establish and apply in vitro, in vivo, and ex vivo assays and models to identify and, characterize novel therapeutics in order , and to select lead candidates
Evaluate novel pathways and mechanisms for immunological therapeutic intervention and formulate strategies for bispecific and combination approaches.
Drive innovation through a deep understanding of the immunology fieldimmunology and the application of new technologies and methods
Manage direct reports
Develop and deliver scientific presentations and reports
Participate in the evaluation of licensing opportunities
Work as part of a highly collaborative interdisciplinary team in an integrated research laboratory
Build strong relationships with peers and cross functionally with partners outside of the team to enable higher performance
Learn fast and can change course quickly where indicated
Strive for rigorous scientific excellenc
Create a learning environment and be open to suggestions and experimentation for improvement
Embrace the ideas of others, nurtures innovation, and manages innovation to reality
PhD; MS; BS in Immunology, Biology, Biochemistry or a related field with 8+ years (PhD); 14+ years (MS); 16+ years (BS) of relevant academic and/or pharmaceutical or biotech experience
Demonstrated expertise in the discovery and development of biologics as therapeutic interventions
Proficiency in a wide range of immunological laboratory techniques
Multi-color flow cytometry (4+ colors)
Identification/sorting/experimentation of T cell/dendritic cell/NK cell biology
Cytotoxic T cell killing
Dendritic cell activation and modulation of the immune response
NK cell killing
Experience/expertise in various High Content Screening (HCS) and High Throughput Screening (HTS) platforms is a plus, but not required
Ability to communicate scientific concepts and strategies effectively in a science setting
Excellent verbal and written communication and interpersonal skills to work across functions and across sites, and within academic and biotech collaborations
Experience leading teams and managing scientists